3, SD&nbsp;=&nbsp;7.2). RESULTS Overall, mobility decline was greater in fallers compared to non-fallers. In fully-adjusted models, higher executive function, but not attention, memory, or visuospatial function, was associated with less decline in mobility among incident fallers. The effect was significantly stronger for those who were older, sedentary, and had lower body mass index. Higher scores in memory tests, but not in other domains, was associated with less mobility decline among non-fallers. CONCLUSIONS Higher executive function may offer resilience to mobility decline after a fall, especially among older adults with other risk factors for mobility decline. Future studies should assess whether executive function may be a helpful risk index of fall-related physical functional decline in geriatric settings. BACKGROUND This study aimed to investigate the efficacy of the Deauville criteria, a 5-point semiquantitative scale criteria to assess the maximum standardized uptake value (SUVmax) of [18F]-?uoro-2-deoxy-D-glucose (FDG) on positron emission tomography (PET)/computed tomography (CT), in predicting lymph node metastasis and other pathological invasive characteristics of early-stage lung adenocarcinoma. METHODS In this retrospective study including 453 patients undergoing lobectomy or segmentectomy with lymph node dissection for clinical T1 or Tis N0 adenocarcinoma between April 2011 and March 2019, the FDG-PET/CT scans were evaluated using the Deauville criteria to analyze the relationship of Deauville score with the clinicopathological characteristics and prognosis. RESULTS The lymph node metastases were present in 0 (0%), 2 (1.1%), 6 (9.5%), 6 (15.8%), and 13 (15.7%) patients with Deauville scores of 1, 2, 3, 4 and 5, respectively. The pathological invasive characteristics (lymphatic, vascular, or visceral pleural invasion) were detected in 2 (2.4%), 17 (9.9%), 18 (28.6%), 23 (60.5%), and 54 (65.1%) patients with Deauville score 1, 2, 3, 4, and 5, respectively. The 3-year recurrence-free survival was longer in the patients with a Deauville score of 1-2 (97.2%) than those with a Deauville score of 3 (86.2%, p less then 0.001) or 4-5 (80.7%, p less then 0.001). CONCLUSIONS The 5-point-scale evaluation of the SUVmax on FDG-PET/CT using the Deauville score was useful in predicting not only lymph node metastasis but also other malignant features of early-stage lung adenocarcinoma. Pulmonary pneumatocele that forms immediately after pulmonary resection is extremely rare. We report a case where a pneumatocele was rapidly formed in the left lower lobe immediately after left upper lobectomy. We noticed massive and persistent air leakage through a chest tube immediately after we closed the chest. https://www.selleckchem.com/products/d609.html Therefore, we re-opened the chest and incised the cyst wall. The air leakage point was cauterized and covered with a polyglycolic acid sheet and fibrin glue. To the best of our knowledge, this is the first case of newly developed pneumatocele immediately after lobectomy. BACKGROUND The optimum priming fluid for the cardiopulmonary bypass (CPB) circuit is still debated. We compared a new hyperoncotic priming solution containing dextran 40, which has an electrolyte composition that mimics extracellular fluid, with a standard crystalloid-based prime. METHODS Eighty cardiac surgery patients were included in this double-blind randomized single-centre study. The patients were randomized to either a dextran-based prime or a crystalloid prime containing Ringer acetate and mannitol. The primary endpoint was colloid oncotic pressure (COP) in serum during CPB. Secondary endpoints included fluid balance, bleeding and transfusion requirements, pulmonary function, hemolysis, systemic inflammation, and markers of renal, hepatic, myocardial, and brain injury. Blood samples were collected before, during, and after CPB. RESULTS COP was higher in the dextran group than in the crystalloid prime group on CPB (18.8±2.9 vs. 16.4±2.9 mmHg, p less then 0.001) and 10 min after CPB (19.2±2.7 vs. 16.8±2.9 mmHg, p less then 0.001). Patients in the dextran group required less intravenous fluid during CPB (1090±499 vs. 1437±543 ml; p=0.003) and net fluid balance was less positive 12h after surgery (+1,431±741 vs. +1,901±922 ml; p=0.014). Plasma free hemoglobin was significantly lower in the dextran group 2h after CPB (0.18±0.11 vs 0.41±0.33, p=0.001). There were no significant differences in bleeding, transfusion requirements, organ function, systemic inflammation, or brain and myocardial injury markers between the groups at any time point. CONCLUSIONS Our results suggest that a hyperoncotic dextran-based priming solution preserves intraoperative COP compared to crystalloid prime. Larger studies with clinically valid endpoints are necessary to evaluate hyperoncotic prime solutions further. BACKGROUND This study was performed to develop and validate a cardiac surgical intensive care risk adjustment model for mixed cardiac surgery based on a few preoperative laboratory tests, extracorporeal circulation time, and measurements at arrival to the intensive care unit (ICU). METHODS A retrospective study of admissions to five cardiac surgical intensive care units in Sweden which submitted data to the Swedish Intensive Care Registry. Admissions from 2008-2014 (n=21,450) were used for model development, while admissions from 2015-2016 (n=6,463) were used for validation. Models were built using logistic regression with transformation of raw values or categorization into groups. RESULTS The final model showed good performance, with an area under the receiver operating characteristics curve of 0.86 (95% confidence interval [CI] 0.83 to 0.89), a Cox calibration intercept of -0.16 (-0.47 to 0.19), and slope of 1.01 (0.89 to 1.13) in the validation cohort. CONCLUSIONS Eleven variables available on admission to the ICU can be used for the prediction of 30-day mortality after cardiac surgery. The model performance was better than those of general intensive care risk adjustment models used in cardiac surgical intensive care and also avoided the subjective assessment of the cause of admission. The standardized mortality ratio improves over time in Swedish cardiac surgical intensive care.